Chemistry Of LSD
D-lysergic acid diethylamide, is a semisynthetic alkaloid of the lysergamide family. It contains a core structure of lysergic acid, with an N,N-diethylamide functional group bound to RN of the chemical structure. This core polycyclic structure of LSD is an indole derivative and has tryptamine and phenethylamine groups embedded within it.
LSD’s structure contains a bicyclic hexahydroindole ring fused to a bicyclic quinoline group (lysergic acid). At carbon 8 of the quinoline an N, generally N-diethyl carboxamide is bound, and is additionally substituted at carbon 6 with a methyl group. It is a chiral compound with two stereo centers at R5 and R8. Also called (+)-D-LSD, has an absolute configuration of (5R, 8R). The three other stereoisomers of LSD do not have psychoactive properties.
Binding affinities for various receptors. The lower the dissociation constant (Ki), the more strongly it binds to that receptor (i.e. with higher affinity).
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